Three months later, a major overhaul was given, but only two issues. The changes have been submitted. It was in review a few days ago and has now become awaiting review. Does anyone know why?

(0) 讚！ | 初见.

If conditions allow, try to make up for the experiment as much as possible. If it is really impossible, then seriously consider defending the reasons, but a humble and cautious tone is indispensable. After all, there is also a certain rejection rate for major revisions

(0) 讚！ | 维尔娜菲茨杰拉德

When replying to the comments from the reviewers, all questions must be addressed one by one without omission; try to fulfill the additional experiments suggested in the comments, if unable to, provide reasonable explanations for why they cannot be done; make sure to cite the literature recommended by the reviewers and discuss thoroughly; when submitting the revised manuscript, double-check the corrections made in the original draft.
If you agree with the modifications suggested by the editor when replying to the editor's comments, simply accept the changes. If you disagree, state your reasons directly below the comment and provide feedback to the editor. In case of conflicting opinions, negotiate further

(0) 讚！ | 维尔娜菲茨杰拉德

What is the difference between responding to referees' comments and responding to the editor's comments?

(0) 讚！ | 北国博达

The reviewer requested that I supplement the experiment, but my samples have run out/experiment is already completed. Will my paper be rejected if I directly say that my samples have run out?

(0) 讚！ | 龙鳞孝礼